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Treatment of Acute Myelogenous Leukemia: A Prospective Controlled Trial of Bone Marrow Transplantation Versus Consolidation Chemotherapy

RICHARD E. CHAMPLIN, M.D.; WINSTON G. HO, M.D.; ROBERT PETER GALE, M.D., Ph.D.; DREW WINSTON, M.D.; MICHAEL SELCH, M.D.; RONALD MITSUYASU, M.D.; CARL LENARSKY, M.D.; ROBERT ELASHOFF, Ph.D.; JACOB ZIGHELBOIM, M.D.; and STEPHEN A. FEIG, M.D.
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Grant support: In part by grant CA 23175 from the National Cancer Institute and grant RR 865 from the United States Public Health Service. Dr. Champlin is a recipient of a New Investigator Research Award, National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases. Dr. Lenarsky is a recipient of an American Cancer Society Junior Faculty Clinical Fellowship. Dr. Mitsuyasu is a recipient of a Clinical Investigator Award from the National Cancer Institute.

▸Requests for reprints should be addressed to Richard Champlin, M.D.; Division Hematology/Oncology, UCLA Center for the Health Sciences; Los Angeles, CA 90024.


Los Angeles, California


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(3):285-291. doi:10.7326/0003-4819-102-3-285
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In a prospective controlled trial, the relative effectiveness of allogeneic bone marrow transplantation and postremission chemotherapy was assessed for adult patients with acute myelogenous leukemia in first complete remission. Twenty-three patients, 15 to 45 years of age, who had an HLA-identical sibling donor were designated to receive bone marrow transplantation. Forty-four patients who either lacked an HLA-identical sibling or were over 45 years of age were designated to receive intensive consolidation chemotherapy. The actuarial rate of leukemia relapse was significantly lower in the transplantation group than in the chemotherapy group (40 ± 25% [95% confidence interval] compared with 71 ± 14%, p = 0.01). Actuarial survival at greater than 4 years was not significantly different (40 ± 21% compared with 27 ± 14%, p > 0.4). These data show that bone marrow transplantation is more effective than consolidation chemotherapy in preventing leukemia relapse, but overall survival was not improved in this study.

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