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Late Relapse Among Patients Treated for Hodgkin's Disease

TERENCE S. HERMAN, M.D.; RICHARD T. HOPPE, M.D.; SARAH S. DONALDSON, M.D.; RICHARD S. COX, Ph.D.; SAUL A. ROSENBERG, M.D.; and HENRY S. KAPLAN, M.D.
[+] Article and Author Information

Grant support: in part by grant CA34233 from the National Cancer Institute, National Institutes of Health.

▸Requests for reprints should be addressed to Richard T. Hoppe, M.D.; Division of Radiation Therapy, Stanford University Medical Center; Stanford, CA 94305.


Stanford, California


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(3):292-297. doi:10.7326/0003-4819-102-3-292
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Of 1360 consecutive patients with Hodgkin's disease treated at Stanford University, 1312 patients (96%) had complete remission, but 424 patients had a relapse. Fifty-five patients had relapses 36 months or more after completion of therapy. The actuarial risk of relapse in patients disease-free 3 years after therapy was 12.9%. The occurrence of late relapse was significantly related to stage I disease and nodular sclerosis histologic subtype. Late relapse was detected in 88% of patients by history, physical findings, or chest radiographs. Most patients with stage III and IV disease had late relapses in previously irradiated nodes or extranodally, but patients with stage I and Il disease had late relapses primarily in unirradiated nodes. Disease-free survival after salvage therapy for late relapse was similar to that seen after treatment of earlier relapse. Prolonged surveillance of patients for late relapse is necessary after treatment of patients with Hodgkin's disease.

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