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Danazol Therapy for Autoimmune Hemolytic Anemia

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▸Requests for reprints should be addressed to Yeon S. Ahn, M.D.; Center for Blood Diseases, University of Miami Hospital and Clinics, 1475 N.W. 12th Avenue; Miami, FL 33136.

Grant support: by the Miami Veterans Administration Merit Review Award 0215-01 and by research funds given in honor of Mary Beth Weiss, Kenneth Chasen, Steven Andrew de Young, H. Spencer Lichte, Drs. Solomon and Renee Papper, and James and Vedna Welch.

Miami, Florida

© 1985 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1985;102(3):298-301. doi:10.7326/0003-4819-102-3-298
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We evaluated the use of danazol in 15 patients with autoimmune hemolytic anemia of the warm antibody type. Danazol, 600 to 800 mg/d, was added to previous regimens or given initially in conjunction with high-dose prednisone treatment. Twelve patients with autoimmune hemolytic anemia associated with nonmalignant disorders or idiopathic autoimmune hemolytic anemia and 1 of 3 patients with underlying neoplasms showed a rise in hematocrit within 1 to 3 weeks. Thereafter, glucocorticoid doses were tapered to a minimum requirement or stopped. Once remission was sustained, the dose of danazol was reduced to 200 to 400 mg/d. Although levels of erythrocyte-bound IgG antibody and C3 decreased with therapy, only the decrease in C3 was statistically significant (p < 0.05) in this limited study. Danazol was effective regardless of the severity of the disorder and success or failure of previous treatments. Danazol is valuable in the treatment of autoimmune hemolytic anemia and may be better suited than glucocorticoids for long-term management.





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