0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Furosemide Absorption Altered in Decompensated Congestive Heart Failure

MICHAEL R. VASKO, Ph.D.; DEBBIE BROWN-CARTWRIGHT, P.A.; JAMES P. KNOCHEL, M.D.; J. V. NIXON, M.D.; and D. CRAIG BRATER, M.D.
[+] Article and Author Information

Grant support: in part by the Veterans Administration. Dr. Brater received grants 1-RO1-AM27059 and 1-KO4-AM00705 from the National Institutes of Health; and the General Clinical Research Center, Dallas, Texas, received USPHS-1MO1 and RR00633.

▸Requests for reprints should be addressed to Michael R. Vasko, Ph.D.; Pharmacology Section (11E), Veterans Administration Medical Center, 4500 S. Lancaster; Dallas, TX 75216.


Dallas, Texas


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(3):314-318. doi:10.7326/0003-4819-102-3-314
Text Size: A A A

We assessed whether patients with decompensated congestive heart failure had altered absorption of oral furosemide. Pharmacokinetic and pharmacodynamic responses were studied in 11 patients receiving their usual oral dose of furosemide while decompensated, and after attaining normal weight. Seven patients also received 25 g of oral D-xylose to further assess intestinal absorption. A 57% decrease in lag time (p = 0.033), a 27% decrease in time to peak serum concentration (p = 0.041), and a 29% increase in the peak serum furosemide concentration (p = 0.008) were seen in compensated as compared to decompensated patients. No significant change was seen in absorption or elimination half-lives, area under the serum concentration versus time curves for furosemide, or in absorption of D-xylose. Although the pharmacodynamics of furosemide were reduced compared to normal subjects, there was little difference in the compensated and decompensated states. Our results show an alteration in furosemide absorption in decompensated congestive heart failure.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)