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Immunoglobulin G Antibodies to Lymphadenopathy-Associated Virus in Differently Treated French and Belgian Hemophiliacs

Ch. ROUZIOUX, Ph.D.; F. BRUN-VEZINET, M.D.; A.M. COUROUCÉ, Ph.D.; C. GAZENGEL, M.D.; D. VERGOZ, M.D.; J. DESMYTER, M.D.; J. VERMYLEN, M.D.; C. VERMYLEN, M.D.; D. KLATZMANN, M.D.; D. GEROLDI, M.D.; C. BARREAU, Ph.D.; F. BARRÉ-SINOUSSI, Ph.D.; J.C. CHERMANN, Ph.D.; D. CHRISTOL, M.D.; and L. MONTAGNIER, M.D.
[+] Article and Author Information

Grant support: by grants from the Pasteur Institute, French National League Against Cancer, Centre National de la Recherche Scientifique (CRNS, France), and the Belgian Fonds de la Recherche Scientifique Médicale.

▸Requests for reprints should be addressed to Ch. Rouzioux, Ph.D.; Hôpital Claude Bernard, Laboratoire Central de Virologie, 10 avenue de la Porte d'Aubervilliers; 75019 Paris, France.


Paris, France; Leuven, Belgium; and Pavia, Italy


©1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(4):476-479. doi:10.7326/0003-4819-102-4-476
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Immunoglobulin G antibodies to lymphadenopathy-associated virus have been detected in two groups of French hemophiliacs and in one group of Belgian hemophiliacs, whose mode of treatment differed. Seropositivity was more frequent (58.9%) in patients heavily transfused with blood products of French and foreign origin than in less frequently transfused persons (10.3%). The Belgian group, treated only with local products, showed the lowest frequency of seropositivity (3.4%). In healthy French controls, 1 of 330 had antibody to the virus. The results indicate transmission of lymphadenopathy-associated virus via blood-derived products.

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