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Chronic Thyroiditis and Mitral Valve Prolapse

ALLAN D. MARKS, M.D.; BERTRAM J. CHANNICK, M.D.; E. VICTOR ADLIN, M.D.; REX K. KESSLER, M.D.; LEONARD E. BRAITMAN, Ph.D.; and BARRY S. DENENBERG, M.D.
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▸Requests for reprints should be addressed to Allan D. Marks, M.D.; Temple University Hospital, Broad and Ontario Streets; Philadelphia, PA 19140.


Philadelphia, Pennsylvania


©1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(4):479-483. doi:10.7326/0003-4819-102-4-479
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Mitral valve prolapse is more prevalent in patients with autoimmune diffuse toxic goiter, suggesting a possible etiologic association. The prevalence of mitral valve prolapse was determined in 75 patients with chronic lymphocytic thyroiditis, another autoimmune thyroid disorder, and in 50 healthy control subjects. Mitral valve prolapse was found in 31 of 75 (41%) patients with chronic lymphocytic thyroiditis and in 4 of 50 (8%) controls (odds ratio, 8.10; 95% confidence interval, 2.64 to 24.83;p < 0.0005). The age-race adjusted odds ratio was 9.26 (95% confidence interval, 2.83 to 30.26; p < 0.0005). No correlation between the prevalence of mitral valve prolapse and the presence of hypothyroidism, serum antithyroid antibodies, or the duration of chronic lymphocytic thyroiditis was found. The prevalence of mitral valve prolapse is substantially increased in patients with the autoimmune thyroid disorders.

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