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Healing of Benign Gastric Ulcer: Comparison of Cimetidine and Placebo in the United States

DAVID Y. GRAHAM, M.D.; KEMAL AKDAMAR, M.D.; WALTER P. DYCK, M.D.; EDWIN ENGLERT Jr., M.D.; ROBERT G. STRICKLAND, M.D.; JAMES L. ACHORD, M.D.; ALPHONSO A. BELSITO, M.D.; Z. RENO VLAHCEVIC, M.D.; ROBERT N. KORNFIELD, M.D.; WILLIAM B. LONG, M.D.; STEPHEN SONTAG, M.D.; and NAURANG M. AGRAWAL, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to David Y. Graham, M.D.; Room 612, Building 1A, Veterans Administration Medical Center, 2002 Holcombe Boulevard; Houston, TX 77211.


Houston and Temple, Texas; New Orleans, Louisiana; Salt Lake City, Utah; Albuquerque, New Mexico; Jackson, Mississippi; St. Paul, Minnesota; Richmond, Virginia; Rochester, New York; Philadelphia, Pennsylvania; and Hines, Illinois


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;102(5):573-576. doi:10.7326/0003-4819-102-5-573
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Recently the Food and Drug Administration approved cimetidine for the treatment of benign gastric ulcer. Approval was based in part on the results of our large multicenter trial involving 172 patients with benign gastric ulcer between 0.5 and 2.5 cm in diameter: 87 were randomly assigned to receive cimetidine (300 mg four times daily) and 85 to receive placebo. Cimetidine treatment resulted in significantly more rapid healing than placebo; after 2 and 6 weeks of therapy, 10.0% and 44.8% of patients receiving placebo were healed, as compared to 22.6% and 65.1% receiving cimetidine. The results of our study were compared with the time-response curve previously published (0, 4, and 8 weeks of therapy). The combined data yielded linear healing rates for the first 8 weeks of therapy (r > 0.99 for both cimetidine and placebo). These studies can be used to define expectations for healing of benign gastric ulcer, and we recommend follow-up intervals of 8 and, if unhealed, 16 weeks.

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