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Danazol Therapy in Myelodysplasia

[+] Article, Author, and Disclosure Information

Grant support: in part by grants HL28220 and CA 16520 from the National Institutes of Health. Dr. Cines is the recipient of Research Career Development Award 1-KO4HL00956 from the National Institutes of Health.

▸Requests for reprints should be addressed to Douglas B. Cines, M.D.; Hospital of the University of Pennsylvania, 3400 Spruce Street, Silverstein 7; Philadelphia, PA 19104.

Philadelphia, Pennsylvania

© 1985 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1985;103(1):58-60. doi:10.7326/0003-4819-103-1-58
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Platelet-associated IgG was markedly elevated in three patients with myelodysplasia and severe thrombocytopenia that had become refractory to platelet transfusions. The patients were treated with danazol because of its efficacy in treating immune thrombocytopenic purpura where platelet destruction is primarily mediated by IgG autoantibodies. After danazol therapy, the platelet counts of each patient rose and clinical bleeding stopped, and a decline in hemolysis was seen in two patients. Danazol probably impeded the peripheral clearance of cells by macrophages; however, a beneficial effect of danazol on hematopoiesis cannot be excluded.





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