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Diagnosis and Treatment |

Cefamandole and Cefoxitin

CHARLES V. SANDERS, M.D.; RICHARD N. GREENBERG, M.D.; and ROBERT L. MARIER, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Charles V. Sanders, M.D.; Louisiana State University Medical Center, Department of Medicine, 1542 Tulane Avenue; New Orleans, LA 70112.


New Orleans, Louisiana; and St. Louis, Missouri.


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;103(1):70-78. doi:10.7326/0003-4819-103-1-70
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Cefamandole and cefoxitin, introduced only 7 years ago, are now the most commonly prescribed parenteral antibiotics in the United States. These drugs are similar to the first-generation cephalosporins in toxicity, but their in-vitro spectrum of activity is greater. Their serum half-lives are longer than those of cephalothin and cephapirin but shorter than that of cefazolin. Although cefamandole has been recommended in empiric therapy for patients with community-acquired pneumonia and as a prophylactic agent for patients having various surgical procedures, other regimens are less expensive and just as effective. Cefamandole should not be used to treat intra-abdominal, enterobacter, or ampicillin-resistant Haemophilus influenzae infections. Cefoxitin is effective in the treatment and prevention of mixed aerobic-anaerobic skin and soft-tissue, intra-abdominal, gynecologic, and penicillinase-producing, spectinomycin-resistant Neisseria gonorrhoeae infections. Cefoxitin represents a greater advance than cefamandole in our continuing search for safe and more effective antimicrobial agents.

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