The full content of Annals is available to subscribers

Subscribe/Learn More  >
Editorials |

Human Growth Hormone and Creutzfeldt-Jakob Disease

[+] Article, Author, and Disclosure Information

National Hormone and Pituitary Program, University of Maryland School of Medicine; Baltimore, Maryland

Ann Intern Med. 1985;103(2):288-289. doi:10.7326/0003-4819-103-2-288
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

The decision of the National Institutes of Health on 19 April 1985 to suspend, temporarily, the distribution of human growth hormone and all other pituitary hormones for clinical research sent shock waves around the world and caused considerable dismay within the United States. The factors leading to this decision were simple, but the interpretation of their significance remains much more difficult.

One 21-year-old patient died of Creutzfeldt-Jakob disease in November 1984. He had had neonatal hypothyroidism, became an insulin-dependent diabetic at 3 years of age, was shown to have hypopituitarism with hypoglycemia, and began receiving human growth hormone in 1966.


First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Topic Collections
PubMed Articles
Seeds of neuroendocrine doubt. Nature 2016;535(7611):E1-2.
Collinge et al. reply. Nature 2016;535(7611):E2-3.
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.