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FAB M7: Acute Megakaryoblastic Leukemia—Beyond Morphology

CLARA D. BLOOMFIELD, M.D.; and RICHARD D. BRUNNING, M.D.
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University of Minnesota Health Sciences Center; Minneapolis, Minnesota


Ann Intern Med. 1985;103(3):450-452. doi:10.7326/0003-4819-103-3-450
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The French-American-British (FAB) leukemia cooperative study group, in this issue (1), adds another category of acute nonlymphocytic leukemia to their classification: acute leukemia of megakaryocyte lineage, or M7. As with prior FAB categories, M7 defines a type of leukemia that has been recognized for many years (2). Recently, as a result of developments in ultrastructural cytochemistry and immunologic phenotyping, acute leukemias of megakaryocytic lineage have been diagnosed increasingly (3-13); at least one group has reported that this type accounts for more than 10% of acute nonlymphocytic leukemias (10). Although a distinct clinical syndrome has not been delineated, it has been

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