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Transient Antibody to Lymphadenopathy-Associated Virus/Human T-Lymphotropic Virus Type III and T-Lymphocyte Abnormalities in the Wife of a Man Who Developed the Acquired Immunodeficiency Syndrome

HAROLD BURGER, Ph.D.; BARBARA WEISER, M.D.; WILLIAM S. ROBINSON, M.D.; JEFFREY LIFSON, M.D.; EDGAR ENGLEMAN, M.D.; CHRISTINE ROUZIOUX, Ph.D.; FRANÇOISE BRUN-VÉZINET, M.D.; FRANÇOISE BARRÉ-SINOUSSI, Ph.D.; LUC MONTAGNIER, M.D.; and JEAN-CLAUDE CHERMANN, Ph.D.
[+] Article, Author, and Disclosure Information

Grant support: in part by grant AI 13526 from the National Institute of Allergy and Infectious Disease, grant R01 HL32453 from the National Heart Lung and Blood Institute, the Institut Pasteur, and the National French League Against Cancer. Drs. Burger and Weiser were supported by Clinical Investigator Awards 5K08 HL01059 and 7K08 HL01481, respectively, from the National Heart Lung and Blood Institute. Dr. Lifson was supported by a fellowship (DRG-021) from the Damon Runyon-Walter Winchell Cancer Fund.

▸Requests for reprints should be addressed to Harold Burger, Ph.D., M.D.; Division of Infectious Diseases, Health Sciences Center T-15, 080, State University of New York at Stony Brook; Stony Brook, NY 11794.


Stanford, California; and Paris, France


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;103(4):545-547. doi:10.7326/0003-4819-103-4-545
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We present evidence of transmission of lymphadenopathy-associated virus (LAV)/human T-lymphotropic virus type III (HTLV-III) from a man to his wife, and a return to a normal number of T-helper lymphocytes and loss of antibody after discontinuing sexual exposure to LAV/HTLV-III. The man had hemophilia A, and developed the lymphadenopathy syndrome, antibody to LAV, and a low number of T-helper lymphocytes. His wife, who had no risks for the acquired immunodeficiency syndrome other than sexual contact with him, developed LAV antibody (titer, 1:160) and a mildly decreased number of T-helper cells. The husband subsequently developed the syndrome and lost the LAV antibody. During 10 months of follow-up his wife remained clinically well, discontinued exposure to semen, and then lost the LAV antibody, and regained a normal number of T-helper cells.

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