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Fluorescent Antinuclear Antibodies and Anti-SS-A/Ro in Patients with Immune Thrombocytopenia Subsequently Developing Systemic Lupus Erythematosus

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▸Requests for reprints should be addressed to John G. Curd, M.D.; Autoimmune Disease Center, Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road; La Jolla, CA 92037.

U.S. Navy Hospital, San Diego; Scripps Clinic and Research Foundation, La Jolla, California

Ann Intern Med. 1985;103(4):548-550. doi:10.7326/0003-4819-103-4-548
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This excerpt has been provided in the absence of an abstract.

A positive test for antinuclear antibodies in a patient with chronic immune thrombocytopenic purpura often presents diagnostic and therapeutic problems. Immune thrombocytopenia is the earliest clinical manifestation in a small percentage (3% to 16%) of patients who subsequently develop systemic lupus erythematosus (1, 2). Early recognition of those patients with immune thrombocytopenia who will ultimately develop more serious manifestations of systemic lupus erythematosus would allow better management of their disease.

The fluorescent antinuclear antibody assay, although positive in patients with systemic lupus erythematosus, is not specific (3). The presence of autoantibodies to certain defined nuclear antigens is commonly associated with


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