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Autoantibodies Against Thyroid Hormones or lodothyronine: Implications in Diagnosis, Thyroid Function, Treatment, and Pathogenesis

SHIGEKI SAKATA, M. D.; SHIGENORI NAKAMURA, M.D.; and KIYOSHI MIURA, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Shigeki Sakata, M.D.; The Third Department of Internal Medicine, Gifu University School of Medicine; Gifu 500, Japan.


Gifu, Japan


© 1985 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1985;103(4):579-589. doi:10.7326/0003-4819-103-4-579
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The presence of antithyroid hormone autoantibodies in the sera of patients with thyroid and nonthyroid disorders is a well-known condition. When circulating thyroid hormones bind to the patients' immunoglobulins, serum levels of total and free thyroid hormones are often in discordance with clinical features. This problem occurs because the autoantibodies can interfere with radioimmunoassays. To avoid inappropriate treatment of such patients, it is clinically important to consider the presence of autoantibodies in patients with unexpectedly high or low total and free thyroid hormone values. We have reviewed the English and Japanese literature, both case reports and basic works, and summarize the incidence of antithyroid hormone autoantibodies, clinical features, effects on appropriate testing of the hypothalamicpituitary-thyroid axis, diagnostic methods for confirming their presence of autoantibodies, treatment of patients with these disorders, and possible pathogenetic mechanisms.

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