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Ovarian Cancer: New Therapeutic Concepts, Renewed Optimism

Ann Intern Med. 1985;103(5):795-797. doi:10.7326/0003-4819-103-5-795
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Epithelial carcinomas of the ovary are the most commonly fatal malignancies arising in gynecologic organs of women in developed countries. Because initial clinical manifestations in more than half of the afflicted women are subtle, discovery of the disease most often occurs in stages involving extrapelvic spread. When biologically malignant, ovarian cancer spreads predominantly by the shedding of cells into the peritoneal cavity and establishment of serosal implants initially distributed to the omentum, pelvic reflections, and diaphragmatic gutters. The factors responsible for development of serosal and other peritoneal tumors, their evolution from premalignant to invasive lesions, and the peculiar biology imparting


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