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Medical and Psychological Problems |

Obesity and Common Genetic Metabolic Disorders

[+] Article, Author, and Disclosure Information

Grant support: HL 30086 and AM 02456 from the National Institutes of Health; a grant from the American Diabetes Association (Per-Henrik Iverius); and by the University of Washington Clinical Research Center (RR-37).

▸Requests for reprints should be addressed to John D. Brunzell, M.D.; Department of Medicine RG-26, University of Washington; Seattle, WA 98195.

Seattle, Washington

© 1985 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1985;103(6_Part_2):1050-1051. doi:10.7326/0003-4819-103-6-1050
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Obesity is a heterogeneous group of disorders in terms of etiology; time of development; adipose tissue characteristics; metabolic abnormalities; and associated morbidity and mortality from coronary disease. The typical patient at risk for coronary artery disease in middle age develops abdominal obesity with hypertrophic fat cells in young adulthood, has hypertension, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and decreased high density lipoprotein (HDL)-cholesterol levels. Two common genetic metabolic disorders—noninsulin-dependent diabetes and familial combined hyperlipidemia—both conform to the prototype, accounting perhaps for a substantial amount of the coronary artery disease associated with obesity.





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