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Aspartame-lnduced Urticaria

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Data were provided by Dr. David G. Hattan from adverse drug reaction reports as of 22 April 1985 made to the Food and Drug Administration Center for Food Safety and Applied Nutrition.

Grant support: by grant 1P50 AI 15322-06 from the National Institutes of Health.

▸Requests for reprints should be addressed to Anthony Kulczycki, Jr., M.D.; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue; St. Louis, MO 63110.

Washington University School of Medicine; St. Louis, Missouri

Ann Intern Med. 1986;104(2):207-208. doi:10.7326/0003-4819-104-2-207
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Aspartame (NutraSweet; G.D. Searle & Co., Skokie, Illinois), the dipeptide composed of aspartic acid and the methyl ester of phenylalanine, is a low-calorie artificial sweetener 180 times sweeter than sucrose (1, 2). Although questions have been raised about its safety (3-5), the Food and Drug Administration (FDA) approved aspartame for use in carbonated beverages in 1983, and currently it is used extensively in diet soft drinks, chewing gums, cereals, desserts, and sugar substitutes. One case of granulomatous panniculitis resulting from aspartame has been documented (6). This report describes a case of aspartame-induced urticaria confirmed by doubleblind challenge.

A 23-year-old white



aspartame ; urticaria

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