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Cryptococcal Disease in Patients with the Acquired Immunodeficiency Syndrome: Diagnostic Features and Outcome of Treatment

ABIGAIL ZUGER, M.D.; EDDIE LOUIE, M.D.; ROBERT S. HOLZMAN, M.D.; MICHAEL S. SIMBERKOFF, M.D.; and JAMES J. RAHAL, M.D.
[+] Article, Author, and Disclosure Information

Presented in part on 14-17 April 1985, at the International Conference on Acquired Immunodeficiency Syndrome, Atlanta, Georgia.

▸Requests for reprints should be addressed to James J. Rahal, M.D.; Division of Infectious Diseases, New York V. A. Medical Center, 24th Street and First Avenue; New York, NY 10010.


New York, New York


©1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;104(2):234-240. doi:10.7326/0003-4819-104-2-234
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Between 1 January 1981 and 1 December 1984, 34 of 396 patients with the acquired immunodeficiency syndrome (AIDS) developed cryptococcal infections. Twenty-six cases are reviewed. Twenty-two patients had brain or meningeal disease; the others had pulmonary disease (2 patients), pericarditis (1 patient), and antigenemia (1 patient). During treatment, 3 patients died of cryptococcosis and 3 died of other causes. Fifteen patients were followed for more than 6 weeks after treatment. Of 8 patients who received no additional amphotericin B, 4 had relapses and died of cryptococcosis within 6 months, 3 died of other causes, and 1 survived. Of 7 patients who received maintenance therapy with amphotericin B, none had relapses, 3 died of other causes, and 4 survived. Our data suggest that maintenance therapy with amphotericin may be needed to prevent relapse in patients with AIDS.

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