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Acute Pancreatitis Associated with Trimethoprim-Sulfamethoxazole

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▸Requests for reprints should be addressed to David R. Antonow, M.D.; Gastroenterology Division, MN 654, University of Kentucky Medical Center, 800 Rose Street; Lexington, KY 40536.

Ann Intern Med. 1986;104(3):363-365. doi:10.7326/0003-4819-104-3-363
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Although a number of therapeutic agents have been associated with acute pancreatitis, carefully documented cases showing recurrence of pancreatitis after reexposure are few. We report the case of a patient who developed acute pancreatitis after receiving trimethoprim-sulfamethoxazole. Readministration of this agent was associated with a prompt recurrence of pancreatitis, strongly suggesting a causal relationship. Physicians should be alert to the possibility of pancreatitis in patients who develop nonspecific abdominal symptoms while receiving trimethoprim-sulfamethoxazole.

A 33-year-old man had been receiving azathioprine and prednisone for 5 years after a cadaver renal transplantation. He was hospitalized after the new onset of generalized seizures.


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