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Chronic Epstein-Barr Virus Infection Associated with Fever and Interstitial Pneumonitis: Clinical and Serologic Features and Response to Antiviral Chemotherapy

ROBERT T. SCHOOLEY, M.D.; ROBERT W. CAREY, M.D.; GEORGE MILLER, M.D.; WERNER HENLE, M.D.; ROBIN EASTMAN, B.S.; EUGENE J. MARK, M.D.; KENNETH KENYON, M.D.; EDWIN O. WHEELER, M.D.; and ROBERT H. RUBIN, M.D.
[+] Article and Author Information

Grant support: in part by grants CA37461, CA33324, and AI14741 from the National Institutes of Health; and by the Mashud Mezerhane B Fund.

▸Requests for reprints should be addressed to Robert T. Schooley, M.D.; Infectious Diseases Unit, Massachusetts General Hospital; Boston, MA 02114.


Boston Massachusetts; New Haven, Connecticut; and Philadelphia, Pennsylvania


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;104(5):636-643. doi:10.7326/0003-4819-104-5-636
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Two patients developed fever, interstitial pneumonitis, and pancytopenia associated with extremely high titers of antibody to replicative antigens of the Epstein-Barr virus. In contrast to most patients seropositive for Epstein-Barr virus, neither patient had an antibody response to the Epstein-Barr nuclear antigen K polypeptide. In addition, virus isolated from one patient had a deletion of the B95-8 type in the EcoRI C region of the genome. An etiologic relation between Epstein-Barr virus replication and the clinical manifestations of this syndrome is further shown by the response of each patient to acyclovir therapy. These patients have a new Epstein-Barr-virus-associated syndrome and provide additional evidence that acyclovir may play a role in therapy for selected patients with Epstein-Barr virus infection.

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