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The Effects of Erythromycin in Patients Treated with Cyclosporine

RAFAEL MARTELL, M.D.; DAVID HEINRICHS, M.D.; CALVIN R. STILLER, M.D.; MORRIS JENNER, M.D.; PAUL A. KEOWN, M.B., Ch.B.; and JOHN DUPRE, M.D.
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▸Requests for reprints should be addressed to Rafael Martell, M.D.; Department of Nephrology and Transplantation, University Hospital, P.O. Box 5339, Station A; London, Ontario, N6A 5A5, Canada.


University Hospital; London, Ontario, Canada


Ann Intern Med. 1986;104(5):660-661. doi:10.7326/0003-4819-104-5-660
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This excerpt has been provided in the absence of an abstract.

The clinical introduction of cyclosporine heralded a new class of immunoregulatory drugs with specific inhibitory effects on T-cell functions and elaborated products (1, 2). Cyclosporine's role in facilitating solid organ transplantation and altering autoimmune responses continues to grow (3). As use of the drug widens, more interactions with other pharmacologic agents will be reported. We report the cases of three patients in a pilot study of the effect of cyclosporine in type 1 diabetes (4) in whom treatment with erythromycin was associated with acutely elevated trough serum levels of cyclosporine and clinical manifestations of acute drug toxicity.

No other drugs

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