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Factors Predicting Survival in Adults with Stage I and II Large-Cell Lymphoma Treated with Primary Radiation Therapy

MARK S. KAMINSKI, M.D.; C. NORMAN COLEMAN, M.D.; THOMAS V. COLBY, M.D.; RICHARD S. COX, Ph.D.; and SAUL A. ROSENBERG, M.D.
[+] Article and Author Information

Grant support: in part by grants CA 05838 and CA 34233 from the National Cancer Institute.

▸Requests for reprints should be addressed to Saul A. Rosenberg, M.D.; Division of Medical Oncology, M211, Stanford University Medical Center, 300 Pasteur Drive; Stanford, CA 94305.


Stanford, California


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;104(6):747-756. doi:10.7326/0003-4819-104-6-747
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The records of 148 consecutive patients with Ann Arbor stage I and II large-cell lymphoma treated with primary radiation therapy with or without adjuvant chemotherapy were analyzed retrospectively for pretreatment prognostic variables and results of treatment. For patients treated with radiation to fields on one side of the diaphragm, the 5-year freedom-from-relapse rate was 25% and the survival rate was 35%, but for those given additional transdiaphragmatic radiation or for those given radiation plus adjuvant chemotherapy, the rates were both approximately 67%. In a multivariate analysis, the only significant pretreatment prognostic variables were the number of sites of involvement and bulk of disease, with relapse as the endpoint. For patients treated with radiation to both sides of the diaphragm or with radiation plus adjuvant chemotherapy, the 5-year freedom-from-relapse rate was 82% for the group with a favorable prognosis (with less than three sites of involvement and a mass size of less than 10 cm) and 55% for those with an unfavorable prognosis.

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