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Identification of Major Prognostic Subgroups of Patients with Large-Cell Lymphoma Treated with m-BACOD or M-BACOD

MARGARET A. SHIPP, M.D.; DAVID P. HARRINGTON, Ph.D.; MARY M. KLATT, M.A.; MAXINE S. JOCHELSON, M.D.; GERALDINE S. PINKUS, M.D.; JESSICA L. MARSHALL, B.S.; DAVID S. ROSENTHAL, M.D.; ARTHUR T. SKARIN, M.D.; and GEORGE P. CANELLOS, M.D.
[+] Article and Author Information

Grant support: in part by grants 5T32CA09172-10, CA01057-01, and CA-06516 from the National Cancer Institute.

▸Requests for reprints should be addressed to George P. Canellos, M.D.; Department of Medicine and Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street; Boston, MA 02115.


Boston, Massachusetts


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;104(6):757-765. doi:10.7326/0003-4819-104-6-757
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One hundred twenty-one patients with diffuse large-cell lymphoma treated with m- or M-BACOD (methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone) were evaluated for pretreatment characteristics predictive for response and survival. Two characteristics, poor performance status and massive bulky disease, were negatively associated with response rate in a multivariate analysis. These two characteristics were also negatively associated with survival in multivariate analysis, as was another factor, an increased number of extranodal sites of disease. These three pretreatment characteristics were used to construct a model containing 12 categories of patients at increasing risk for relapse and shortened survival. These categories divided naturally into three broad groups of patients with respective 5-year survival rates of 68%, 55%, and 24%.

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