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Osteoporosis in Men with Hyperprolactinemic Hypogonadism

SUSAN L. GREENSPAN, M.D.; ROBERT M. NEER, M.D.; E. CHESTER RIDGWAY, M.D.; and ANNE KLIBANSKI, M.D.
[+] Article and Author Information

Grant support: by grant RR-01066 from the National Institutes of Health. Dr. Klibanski is the recipient of a Clinical Associate Physician Award from the National Institutes of Health.

▸Requests for reprints should be addressed to Anne Klibanski, M.D.; Thyroid Unit, Bulfinch Basement, Massachusetts General Hospital; Boston, MA 02114.


Boston, Massachusetts


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;104(6):777-782. doi:10.7326/0003-4819-104-6-777
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To ascertain the effects of chronic hyperprolactinemia and testosterone deficiency on skeletal integrity in men, we measured forearm bone density and hormone concentrations in 18 men aged 30 to 79 who had prolactin-secreting pituitary tumors. We also measured vertebral bone density in 12 of the men. Patients with hyperprolactinemia had significant decreases in both forearm (p < 0.001) and vertebral bone density (p = 0.003) compared with age-matched controls. Cortical osteopenia was significantly related to the duration of hyperprolactinemia (p < 0.01) but not to the absolute levels of prolactin or androgens. Seven patients had longitudinal follow-up measurements of forearm bone density. Normalization of serum levels of prolactin or testosterone was associated with an increase in forearm bone density (p < 0.05). These data show that chronic hyperprolactinemia and testosterone deficiency in men have deleterious and previously unrecognized extragonadal effects that may be alleviated after normalization of hormone concentrations.

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