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Increased Helper/Suppressor T-Lymphocyte Ratio in the Cerebrospinal Fluid of a Patient with Neurosarcoidosis

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▸Requests for reprints should be addressed to Richard I. Rynes, M.D.; Division of Rheumatology, Albany Medical College; Albany, NY 12208.

Albany Medical College; Albany, New York

Ann Intern Med. 1986;104(6):807-808. doi:10.7326/0003-4819-104-6-807
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Sarcoidosis has been characterized by abnormal immunologicactivity at the site of active pulmonary disease. Analysis of T-lymphocyte populations has shown an increasedhelper/suppressor (T4/T8) ratio among lymphocytesobtained by bronchoalveolar lavage, and a concomitantdecrease in the T4/T8 ratio in the blood (1). Central nervous system sarcoidosis, a rare manifestation of the disease, has been associated with increased morbidityand mortality (2). We present evidence that during active central nervous system sarcoidosis, T lymphocytes in the central nervous system show abnormalities analogousto those in the lung.

A 21-year-old white man with biopsy-proven sarcoidosis was hospitalized at Albany Medical Center Hospital in June 1985. Sarcoidosis


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