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Urgent Treatment of Idiopathic Thrombocytopenic Purpura with Single-Dose Gammaglobulin Infusion Followed by Platelet Transfusion

[+] Article and Author Information

▸Requests for reprints should be addressed to Michael Baumann, M.D.; Department of Medicine 111W, Wright State University and Veterans Administration Medical Center, 4100 West Third Street; Dayton, OH 45428.

Medical College of Wisconsin and the Blood Center of Southeastern Wisconsin; Milwaukee, Wisconsin

Ann Intern Med. 1986;104(6):808-809. doi:10.7326/0003-4819-104-6-808
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Intravenous administrations of high-dose gammaglobulin increases the peripheral blood platelet counts of most patients with idiopathic thrombocytopenic purpura (1-8). The mechanism of this effect has been thought to be a "blockade" by exogenous immunoglobulin of Fc receptors on phagocytic macrophages, with resultant inhibition of binding and removal from circulation of immunoglobulin-coated platelets (2, 8). Unfortunately, therapy as previously reported entails administration of a dose of 1.0 to 2.0 g/kg body weight given over 4 to 5 days (1-8), at a cost of approximately $6000 for a 5-day course in a person weighing 70 kg. Because responses are usually transient (1-8),


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