0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Reviews |

Linear Scleroderma: Clinical Spectrum, Prognosis, and Laboratory Abnormalities

VINCENT FALANGA, M.D.; THOMAS A. MEDSGER Jr., M.D.; MORRIS REICHLIN, M.D.; and GERALD P. RODNAN, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Vincent Falanga, M.D.; Department of Dermatology, University of Pittsburgh, 3601 Fifth Avenue; Pittsburgh, PA 15213.


▸From the Department of Dermatology and the Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; and the Arthritis and Immunology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.†Dr. Gerald Rodnan is deceased.

Pittsburgh, Pennsylvania; and Oklahoma City, Oklahoma


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;104(6):849-857. doi:10.7326/0003-4819-104-6-849
Text Size: A A A

The clinical features and natural history of linear scleroderma in 53 patients and the laboratory tests helpful in the management of this disease are described. No patient had Raynaud's phenomenon or signs of systemic connective tissue disease in a mean follow-up of 10 years. Blood eosinophilia (> 300 cells/mm3) was present in half the patients, usually those with clinically active disease rather than inactive disease (p < 0.02). An elevated serum IgG level correlated with the presence of joint contractures (p < 0.02). Antinuclear antibodies, commoner in patients with extensive and prolonged disease, were present in 31% and 46% of patients whose sera were tested on mouse kidney and HEp-2 cells, respectively. Antibodies to single-stranded DNA, present in 50% of patients, were associated with extensive disease, joint contractures (p < 0.001), and active disease of greater than 2 years' duration (p < 0.001). Discordance in immune reactivity indicates that at least three serum autoantibodies exist in these patients: antibodies to single-stranded DNA and antinuclear antibodies with homogeneous and nucleolar immunofluorescence patterns.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Topic Collections
PubMed Articles
Health-Related Quality of Life in Morphea. Br J Dermatol Published online Dec 6, 2014.;
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)