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MOPP/ABVD Chemotherapy for Advanced Hodgkin's Disease

Ann Intern Med. 1986;104(6):876-878. doi:10.7326/0003-4819-104-6-876
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In the past 2 decades, the prognosis of patients with advanced Hodgkin's disease has improved dramatically because of the development of curative combination chemotherapy. The MOPP regimen (mechlorethamine, vincristine, procarbazine, prednisone) represents the standard against which all alternative chemotherapy or combined modality programs must be judged. The landmark studies of DeVita and colleagues (1) have shown that more than 50% of patients with advanced Hodgkin's disease are cured with chemotherapy alone. Subsequent studies, both by single institutions and cooperative groups, have confirmed the effectiveness of MOPP chemotherapy (2, 3). The importance of administering full doses of MOPP in a timely


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