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Treatment of Donor Bone Marrow with Monoclonal Anti-T-Cell Antibody and Complement for the Prevention of Graft-Versus-Host Disease: A Prospective, Randomized, Double-Blind Trial

RONALD T. MITSUYASU, M.D.; RICHARD E. CHAMPLIN, M.D.; ROBERT PETER GALE, M.D., Ph.D.; WINSTON G. HO, M.D.; CARL LENARSKY, M.D.; DREW WINSTON, M.D.; MICHAEL SELCH, M.D.; ROBERT ELASHOFF, Ph.D.; JANIS V. GIORGI, Ph.D.; JOHN WELLS, Ph.D.; PAUL TERASAKI, Ph.D.; RONALD BILLING, Ph.D.; and STEPHEN FEIG, M.D.
[+] Article and Author Information

Grant support: in part by grants CA-23175, CA-16042, and RR-00865 from the National Institutes of Health; and grant G830332 from the California Institute for Cancer Research. Dr. Mitsuyasu is a recipient of a Clinical Investigator Award from the National Cancer Institute (K08CA 932) and a Junior Faculty Clinical Fellowship from the American Cancer Society. Dr. Lenarsky is a recipient of a Junior Faculty Clinical Fellowship from the American Cancer Society. Dr. Champlin is a recipient of a New Investigator Research Award from the National Institutes of Arthritis, Diabetes, Digestive and Kidney Diseases.

Presented in part in August 1984 at the Tenth International Congress of The Transplantation Society, Minneapolis, Minnesota.

▸Requests for reprints should be addressed to Ronald T. Mitsuyasu, M.D.; Department of Medicine, Division of Hematology-Oncology, UCLA Center for the Health Sciences; Los Angeles, CA 90024.


Los Angeles, California


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;105(1):20-26. doi:10.7326/0003-4819-105-1-20
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The effects of ex-vivo depletion of T lymphocytes from donor bone marrow using a monoclonal anti-T-cell antibody (CT-2) and complement on the outcome of allogeneic bone marrow transplantation was evaluated in a prospective, randomized, double-blind study of 40 patients with leukemia. Patients receiving T-cell-depleted bone marrow had a lower incidence of acute graft-versus-host disease than control patients (3 of 20 compared with 13 of 20; p = 0.004), and mortality due to acute graft-versus-host disease was reduced. Five patients in the T-cell-depletion group developed graft failure; all control patients had sustained engraftment (p < 0.05). Clinically apparent relapse of leukemia occurred in 7 patients from the T-cell-depletion group and in 2 controls (p, not significant). Cytogenetic evidence of residual leukemia was also detected in the 5 patients with graft failure without overt relapse. Infections and overall survival were similar in the two groups. The effects of T-cell depletion on engraftment and recurrence of leukemia require further evaluation.

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