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Glucagon Reversal of Hypotension in a Case of Anaphylactoid Shock

GARY P. ZALOGA, M.D.; WILLIAM DELACEY, M.D.; ERIC HOLMBOE, M.D.; and BART CHERNOW, M.D.
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The opinions expressed herein are those of the authors and are not to be construed as reflecting the views of the Navy, the Naval Service at large, or of the Department of Defense.

▸Requests for reprints should be addressed to Bart Chernow, M.D.; Department of Anesthesiology, Massachusetts General Hospital; Boston, MA 02114.


Naval Hospital and Uniformed Services University of the Health Sciences; Bethesda, Maryland


Ann Intern Med. 1986;105(1):65-66. doi:10.7326/0003-4819-105-1-65
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This excerpt has been provided in the absence of an abstract.

Generalized anaphylactoid reactions are acute life-threatening emergencies requiring prompt and aggressive therapy, usually with beta-adrenergic compounds such as epinephrine (1). However, beta-adrenergic agonists may be ineffective in reversing hypotension in patients receiving beta-adrenergic blocking agents (2). We report the case of a patient treated with these agents who developed hypotension after radiocontrast dye injection. Hypotension was effectively reversed after the intravenous administration of glucagon.

A 75-year-old white man was transferred to the intensive care unit for treatment of a generalized anaphylactoid reaction. The patient had been scheduled for computed tomography of his head for the evaluation of new-onset vertigo. Within

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