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Liposomal Amphotericin B in the Treatment of Fungal Infections

Ann Intern Med. 1986;105(1):130-131. doi:10.7326/0003-4819-105-1-130
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The successful development of drug carriers as tools to enhance the therapeutic index of known active drugs will depend on the appropriate selection of drug, drug carrier, and disease target. The use of liposomes as carriers for amphotericin B illustrates the feasibility of such an approach. Amphotericin B, a polyene antibiotic, is the mainstay of therapy for most systemic fungal infections and is also an effective agent for treating leishmaniasis. Its use is limited, however, by its severe acute and chronic side effects, particularly acute fever, chills, and electrolyte disturbances. Chronic administration of the drug leads invariably to decreased kidney


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