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Value of Echocardiographic Measurement of Left Ventricular Mass in Predicting Cardiovascular Morbid Events in Hypertensive Men

PAUL N. CASALE, M.D.; RICHARD B. DEVEREUX, M.D.; MARK MILNER, M.D.; GERARDO ZULLO, B.S.; GREGORY A. HARSHFIELD, Ph.D.; THOMAS G. PICKERING, M.D., Ph.D.; and JOHN H. LARAGH, M.D.
[+] Article and Author Information

Grant support: in part by SCOR grant HL-18323 from the National Heart, Lung, and Blood Institute.

Presented in abstract form at the 58th Scientific Sessions of the American Heart Association Meeting, 12 November 1985.

▸Requests for reprints should be addressed to Richard B. Devereux, M.D.; Division of Cardiology, Box 222, The New York Hospital-Cornell Medical Center, 525 East 68th Street; New York, NY 10021.


New York, New York


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;105(2):173-178. doi:10.7326/0003-4819-105-2-173
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To assess whether echocardiographic and electrocardiographic detection of left ventricular hypertrophy could predict cardiovascular morbid events in patients with uncomplicated essential hypertension, we followed 140 men for a mean of 4.8 years. Initial echocardiographic measurements of left ventricular mass were normal (< 125 g/m2 body surface area) in 111 patients and revealed hypertrophy in 29 patients. Morbid events occurred in more patients with hypertrophy on echocardiography (7 of 29,4.6/100 patient-years) than with normal ventricular mass (7 of 111,1.4/100 patient-years; p < 0.01). Electrocardiography showed hypertrophy in too few patients to be of predictive value. Multiple logistic regression analysis showed that left ventricular mass index had the highest independent relative risk for future events and that systolic and diastolic pressures and age had slightly lower relative risks. In men with mild uncomplicated hypertension, left ventricular hypertrophy detected by echocardiography identifies patients at high risk for cardiovascular morbid events and is a significant risk factor for future morbid events independent of age, blood pressure, or resting ventricular function.

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