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Unstable Angina Associated with Factor VIII Concentrate Therapy for Hemophilia A

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▸Requests for reprints should be addressed to Robert G. Kopitsky, M.D.; Box 8086, Cardiovascular Division, Washington University School of Medicine, 660 S. Euclid Ave.; St. Louis, MO 63110.

Washington University School of Medicine; St. Louis, Missouri .

Ann Intern Med. 1986;105(2):215-216. doi:10.7326/0003-4819-105-2-215
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The importance of intracoronary thrombosis in patients with atherosclerotic coronary stenosis has been well established in the pathogenesis of acute transmural myocardial infarction (1). Recent angiographic studies have shown that intracoronary thrombi also occur in many patients who have unstable angina without myocardial infarction (2-5). In patients with severe atherosclerotic coronary obstruction, it is conceivable that a severe coagulation defect could partially protect against unstable angina or acute myocardial infarction by impairing the ability to form intracoronary thrombi; correction of the defect could negate this protection. We describe a case of severe unstable angina associated with the use of factor


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