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Higher Risk of Lung Cancer in Chronic Obstructive Pulmonary Disease: A Prospective, Matched, Controlled Study

DAVID M. SKILLRUD, M.D.; KENNETH P. OFFORD, M.S.; and R. DREW MILLER, M.D.
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Presented in part at the Annual Meeting of the American Thoracic Society, Anaheim, California, 12-15 May 1985.

Requests for reprints should be addressed to R. Drew Miller, M.D.; Division of Thoracic Diseases and Internal Medicine, Mayo Clinic, 200 First Street S.W.; Rochester, MN 55905.


Rochester, Minnesota


©1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;105(4):503-507. doi:10.7326/0003-4819-105-4-503
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To assess the risk of lung cancer in patients with chronic obstructive pulmonary disease, we matched, on the basis of age, sex, occupation, and smoking history, 113 persons ("cases") who had a forced expiratory volume in 1 second (FEV1) of 70% or less of predicted normal with 113 control persons who had an FEV1 of 85% or more. All persons were observed from 1973-74 through 1984 for a diagnosis of lung cancer, death from lung cancer, and death from any cause. At entry, subjects had an age range of 45 to 59 years; men numbered 186 and women 40. Histologically proven lung cancer developed in 9 cases and in 2 controls, all men. The rate of development of lung cancer was significantly different in the two groups (p = 0.024): the 10-year cumulative percentage was 8. 8% for cases and 2.0% for controls. Overall 10-year survival was estimated to be 74.0% for cases and 91.1% for controls (p < 0.001).

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