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Resolution of a Contraceptive-Steroid-Induced Hepatic Adenoma with Subsequent Evolution into Hepatocellular Carcinoma

STUART C. GORDON, M.D.; K. RAJENDER REDDY, M.D.; ALAN S. LIVINGSTONE, M.D.; LENNOX J. JEFFERS, M.D.; and EUGENE R. SCHIFF, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Eugene R. Schiff, M.D.; Division of Hepatology (111H), Veterans Administration Medical Center, 1201 N.W. 16th Street; Miami, FL 33125.


Center for Liver Diseases, University of Miami School of Medicine; and the Veterans Administration Medical Center; Miami, Florida


Ann Intern Med. 1986;105(4):547-549. doi:10.7326/0003-4819-105-4-547
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This excerpt has been provided in the absence of an abstract.

The causal relationship between contraceptive steroids and hepatic adenomas is well established (1). A similar etiologic relationship between contraceptive steroids and hepatocellular carcinoma remains unsettled. Furthermore, whether known contraceptive-steroid-related adenomas may dedifferentiate into hepatocellular carcinoma is equally uncertain. We report the case of a woman in whom an hepatocellular carcinoma arose in an area where a contraceptive-steroid-induced adenoma had previously regressed.

In August 1977, a 36-year-old white woman presented with epigastric fullness and a palpable mass in her right upper abdomen. The patient had been taking contraceptive steroids for the previous 14 years and, specifically, a combination agent containing norethindrone

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