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Calcium-Regulating Hormones in Essential Hypertension: Relation to Plasma Renin Activity and Sodium Metabolism

LAWRENCE M. RESNICK, M.D.; FRANCO B. MÜLLER, M.D.; and JOHN H. LARAGH, M.D.
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Portions of this study were published in abstract form and presented at the IXth International Congress of Nephrology in June 1984.

▸Requests for reprints should be addressed to Lawrence M. Resnick, M.D.; The New York Hospital-Cornell Medical Center, Cardiovascular Center, 525 East 68th Street; New York, NY 10021.


New York, New York


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;105(5):649-654. doi:10.7326/0003-4819-105-5-649
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Circulating levels of the calcium-regulating hormones, calcitonin, calcitriol, and parathyroid hormone, were analyzed in relation to plasma renin activity in 10 persons with normal blood pressure and in 51 persons with essential hypertension. Calcitriol (p < 0.008) and parathyroid hormone (p < 0.01) levels were elevated in hypertensives with low renin activity, whereas calcitonin levels were higher in patients with high renin activity (p < 0.008), compared with normotensive controls and other hypertensive patients. Continuous relationships were observed between calcitriol levels and plasma renin activity in all patients (r = -0.65, p < 0.001) and between parathyroid hormone levels and urinary sodium excretion in hypertensive patients with low renin activity (r = -0.63, p < 0.01). Together, these results support a linkage between calcium metabolism and renin-sodium factors in essential hypertension. Calcium-regulating hormones and the renin-aldosterone system may coordinately mediate the blood pressure effects of differing dietary calcium and sodium intakes at the cellular level by altering cellular handling of monovalent and divalent ions.

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