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Non-Hodgkin's Lymphoma After Treatment of Hodgkin's Disease: Association with Epstein-Barr Virus

ALAN F. LIST, M.D.; JOHN P. GREER, M.D.; JOHN B. COUSAR, M.D.; RICHARD S. STEIN, M.D.; JOHN M. FLEXNER, M.D.; FARUK SINANGIL, Ph.D.; JACK DAVIS, B.Sc.; DAVID J. VOLSKY, Ph.D.; and DAVID T. PURTILO, M.D.
[+] Article and Author Information

Grant support: in part by grants CA30196 from the National Cancer Institute, LB506 from the Nebraska Department of Health, and a grant from the Lymphoproliferative Fund.

▸Requests for reprints should be addressed to John P. Greer, M.D.; Division of Hematology, Room C-3119, MCN, Vanderbilt University Medical Center; Nashville, TN 37232.


Nashville, Tennessee; and Omaha, Nebraska


© 1986 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1986;105(5):668-673. doi:10.7326/0003-4819-105-5-668
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Non-Hodgkin's lymphoma occurs infrequently as a late complication of obscure cause after treatment of Hodgkin's disease. We investigated the possible role of Epstein-Barr virus in the pathogenesis of such secondary malignancies of B-cell lineage. Two patients, aged 25 and 43 years, developed high-grade non-Hodgkin's lymphomas 12 and 8 years after radiation therapy for Hodgkin's disease. Serologic profiles in these patients showed evidence of acute and past Epstein-Barr virus infections, respectively. Molecular hybridization analysis showed the presence of multiple cellular equivalents of virus genome in tumor specimens from each patient. Our findings suggest that Epstein-Barr virus may play an integral role in the pathogenesis of non-Hodgkin's lymphoma of B-cell lineage that develops after treatment of Hodgkin's disease.

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