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Persistence of Trophozoites After Successful Treatment of Pneumocystis carinii Pneumonia

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▸Requests for reprints should be addressed to Wafaa El-Sadr, M.D.; Infectious Disease Section, Veterans Administration Medical Center, 408 First Avenue; New York, NY 10010.

New York University Medical Center; and the New York Veterans Administration Medical Center; New York, New York

Ann Intern Med. 1986;105(6):889-890. doi:10.7326/0003-4819-105-6-889
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Pneumocystis carinii pneumonia has grown in importance due to the special predilection of patients with the acquired immunodeficiency syndrome (AIDS) to develop this infection. More than 60% of such patients develop P. carinii pneumonia and about 20% have a recurrence (1). We report a case of a patient with AIDS and P. carinii pneumonia in whom a repeat biopsy after clinical response to therapy with trimethoprim-sulfamethoxazole failed to show P. carinii cysts while electron microscopy showed many trophozoites of P. carinii.

A 37-year-old intravenous drug abuser was hospitalized with a 2-month history of fever and cough. The patient had a


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