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Diagnosis and Treatment |

Radioiodine Treatment of Graves' Disease: An Assessment of Its Potential Risks

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▸Requests for reprints should be addressed to Kenneth D. Burman, M.D.; Endocrinology Service, Clinic 7D, Walter Reed Army Medical Center; Washington, DC 20307-5001.

Washington, D.C.; and Bethesda, Maryland

Ann Intern Med. 1986;105(6):900-905. doi:10.7326/0003-4819-105-6-900
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Concern about the side effects of radiation exposure has deterred physicians from using radioiodine treatment for Graves' disease, although the efficacy and safety of this treatment have been established in the 35 years since its introduction. In that time, no significant side effects have been discovered. We believe iodine-131 should be considered the treatment of choice in most patients with Graves' disease. This article reviews the current understanding of the risks in radioiodine treatment of Graves' disease, including the risks for teratogenicity, genetic damage, carcinogenesis, and cellular dysfunction.





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