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The Clinical Significance of Campylobacter pylori

CORNELIUS P. DOOLEY, M.D.; and HARTLEY COHEN, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to Cornelius P. Dooley, M.D.; Gastroenterology Section, Department of Medicine, USC School of Medicine, 2025 Zonal Avenue; Los Angeles, CA 90033.


Los Angeles, California


© 1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;108(1):70-79. doi:10.7326/0003-4819-108-1-70
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Campylobacter pylori has recently been isolated from gastric mucosal biopsy specimens. Campylobacter pylori has many attributes in common with other Campylobacters but it may represent a new genus. It produces abundant quantities of urease, and this property has been used to develop a rapid diagnostic test. The organism is found predominantly beneath the gastric mucus layer that lines the surface epithelium of the stomach. Infection with C. pylori causes an acute histologic gastritis which may become chronic. The bacterium is the etiologic agent in type-B gastritis. Prevalence of the organism in asymptomatic persons appears to be age related. Campylobacter pylori is found commonly in patients with peptic ulcer disease, always in association with chronic gastritis. Eradication of the organism is associated with healing of the gastritis and a lower relapse rate in duodenal ulcer disease. A role for the organism in other upper gastrointestinal diseases is unproven.

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