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Lipids and Lipoprotein Changes After Heart and Liver Transplantation in a Patient with Homozygous Familial Hypercholesterolemia

P. VALDIVIELSO, M.D.; J. L. ESCOLAR, M.D.; V. CUERVAS-MONS, M.D.; L. A. PULPÓN, M.D.; M. A. S. CHAPARRO, M.D.; and P. GONZÁLEZ-SANTOS, M.D.
[+] Article and Author Information

▸Requests for reprints should be addressed to P. Valdivielso, M.D.; Cátedra de Patología General, Facultad de Medicina, Universidad de Málaga, Colonia de Santa Inés; Málaga-29080, Spain.


Málaga and Madrid, Spain


© 1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;108(2):204-206. doi:10.7326/0003-4819-108-2-204
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Changes in lipids and lipoprotein fractions were studied 6 months after a combined heart and liver transplantation in a patient with terminal ischemic heart disease due to homozygous familial hypercholesterolemia. The double transplant was followed by striking decreases in total and low-density-lipoprotein cholesterol levels (- 71% and - 79%) and content of apolipoprotein B in the low-density-lipoprotein fraction (- 74%). There was also an increase in high-density-lipoprotein cholesterol (+ 7.8%). These changes are greater than those reported with portacaval shunt or plasma exchange. Liver transplantation may be considered in selected patients with homozygous familial hypercholesterolemia.

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