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Metoclopramide-Induced Agranulocytosis

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▸Requests for reprints should be addressed to Roger L. Harvey, D.O.; Division of Infectious Diseases, Hutzel Hospital, 4707 St. Antoine; Detroit, MI 48201.

Western Reserve Care System; Youngstown, Ohio

Ann Intern Med. 1988;108(2):214-215. doi:10.7326/0003-4819-108-2-214
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Adverse side effects occur in up to 20% of patients receiving metoclopramide treatment (Reglan, A.H. Robbins Co., Richmond, Virginia) (1). Agranulocytosis has not been described previously. Two unpublished reports suggest metoclopramide may have caused agranulocytosis (Board A, A.H. Robbins Co., Personal communication). The first case involved the use of metoclopramide and triamterene; the second case involved the use of metoclopramide and acetaminophen. These patients were not rechallenged with metoclopramide or other agents. In several other unpublished reports, patients received multiple drug regimens and no clear causal relationship could be determined. A few patients were rechallenged with metoclopramide without adverse side


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