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Human Immunodeficiency Virus (HIV) Infection of the Uterine Cervix

ROGER J. POMERANTZ, M.D.; SUZANNE M. de la MONTE, M.D.; S. PATRICK DONEGAN, M.D.; TERESA R. ROTA, M.A.; MARKUS W. VOGT, M.D.; DONALD E. CRAVEN, M.D.; and MARTIN S. HIRSCH, M.D.
[+] Article and Author Information

Grant support: in part by National Institutes of Health Grants CA 12464 and CA35020; and Massachusetts Department of Public Health Grant 2202-80-70109. Roger J. Pomerantz, M.D., was supported by National Institutes of Health Training Grant T32AI07061.

▸Requests for reprints should be addressed to Roger J. Pomerantz, M.D.; Infectious Disease Unit, Gray 4, Massachusetts General Hospital, Fruit Street; Boston, MA 02114.


BOSTON, MASSACHUSETTS


© 1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;108(3):321-327. doi:10.7326/0003-4819-108-3-321
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Human immunodeficiency virus (HIV) has been detected in cervical secretions from HIV-infected women. We report the isolation of HIV from four cervical biopsy specimens. Cervicitis was shown by immunohistochemical staining in cervical biopsy specimens from four HIV-seropositive women; cervicitis was not found in cervical biopsy specimens from four HIV-seronegative women. We found HIV antigens in monocyte-macrophages and endothelial cells within the submucosa of three of these cervices by specific immunohistochemical staining. Small numbers of HIV-infected cells resembling lymphocytes also were found in the cervical mucosa. The virus was not shown by culture or immunohistochemistry in cervical biopsy specimens from the four HIV-seronegative women. These findings suggest that HIV enters cervical secretions from selected infected cell populations within the cervical tissue. The HIV-infected cells in cervical tissue may be involved in transmission of HIV by heterosexual contact and to neonates born to HIV-infected women.

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