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Cryptococcal Meningitis in the Acquired Immunodeficiency Syndrome (AIDS): Successful Treatment with Fluconazole after Failure of Amphotericin B

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The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or U.S. Government.

▸Requests for reprints should be addressed to Technical Publications Editor; Letterman Army Medical Center, Presidio of San Francisco, CA 94129-6700.

Letterman Army Medical Center, San Francisco, California; and Central Research Pfizer, Inc., Groton, Connecticut.

Ann Intern Med. 1988;108(3):384-385. doi:10.7326/0003-4819-108-3-384
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This excerpt has been provided in the absence of an abstract.

Cryptococcal meningitis, a common complication of the acquired immunodeficiency syndrome (AIDS), is usually associated with a high mortality (1) and the need for lifelong therapy with amphotericin B (2). Fluconazole is a recently developed triazole compound that acts against Cryptococcus neoformans in vitro, shows efficacy in an animal model of cryptococcal meningitis, and has good penetration into cerebrospinal fluid (3). Fluconazole therapy has been used successfully to treat a patient with AIDS who had a relapse of cryptococcal meningitis (4), when retreatment with amphotericin B and 5-flucytosine was contraindicated because of granulocytopenia. A determination of the relative efficacy of treatment


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