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Are Booster Doses of Hepatitis B Vaccine Necessary?

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▸Requests for reprints should be addressed to Stephen C. Hadler, M.D.; Building 6, Room 154, Hepatitis Branch, Centers for Disease Control; Atlanta, GA 30333.

Centers for Disease Control; Atlanta, Georgia

Ann Intern Med. 1988;108(3):457-458. doi:10.7326/0003-4819-108-3-457
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Hepatitis B vaccines have been shown to be highly effective for preventing hepatitis B for several years or more in many populations at high risk worldwide. Attention has now turned to establishing the duration of protection offered by the vaccine and the need for vaccine booster doses. In the United States, the licensed vaccine has been widely available for more than 5 years, which is the duration of reliable protection originally estimated by the vaccine's manufacturer. However, published studies have not yet shown a decline in the protection offered by the vaccine, and booster doses of vaccine have not yet


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