0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Brief Communications |

Antinuclear Autoantibodies Specific for Lamins: Characterization and Clinical Significance

KAISS LASSOUED, M.D.; MARIE-NOELLE GUILLY, Ph.D.; FRANÇOISE DANON, M.D.; CHANTAL ANDRE, M.D.; DANIEL DHUMEAUX, M.D.; JEAN-PIERRE CLAUVEL, M.D.; JEAN-CLAUDE BROUET, M.D.; MAXIME SELIGMANN, M.D.; and JEAN-CLAUDE COURVALIN, M.D.
[+] Article and Author Information

Grant support: Kaiss Lassoued, M. D., received a grant from the Fondation de la Recherche Médicale.

▸Requests for reprints should be addressed to Maxime Seligmann, M.D.; Laboratory of Immunochemistry and Immunopathology, INSERM U 108, Hôpital Saint-Louis, rue Claude Vellefaux; 75475 Paris Cedex 10, France.


Paris, Gif-sur-Yvette, and Créteil, France


© 1988 American College of PhysiciansAmerican College of Physicians


Ann Intern Med. 1988;108(6):829-833. doi:10.7326/0003-4819-108-6-829
Text Size: A A A

In 11 patients, sera displaying a ringlike nuclear immunofluorescent staining on sections of rat liver tissue were shown by Western blotting to contain antibodies to lamins. Sera from 8 patients contained autoantibodies reacting with lamin B, whereas sera from the other 3 patients reacted with lamins A and C. All patients (9 women and 2 men) had a chronic autoimmune disorder, which rarely fulfilled the usual criteria for a diagnosis of systemic lupus erythematosus. The disorder was characterized by acute or chronic (active or granulomatous) hepatitis; steroid-responsive blood cytopenia, often associated with a circulating anticoagulant, or anticardiolipin antibodies, or both; and cutaneous leukocytoclastic angiitis or probable brain vasculitis. Eight patients had at least two of these three conditions. Antilamin autoantibodies may thus be a marker for an unusual subset of autoimmune diseases.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Topic Collections
PubMed Articles

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)