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Collagenous Colitis

HUGO RAMS, M.D.; ARVEY I. ROGERS, M.D.; and LATIFA GHANDUR-MNAYMNEH, M.D.
[+] Article and Author Information

Presented in part at the 79th Annual Scientific Assembly of the Southern Medical Association, Orlando, Florida, 19 November 1985.

▸Requests for reprints should be addressed to Arvey I. Rogers, M.D.; G.I. Section (111-B), Veterans Administration Medical Center, 1201 N.W. 16th Street; Miami, FL 33125.


Miami, Florida


Ann Intern Med. 1987;106(1):108-113. doi:10.7326/0003-4819-106-1-108
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Two hypotheses have been proposed to explain the pathogenesis and cause of the increased subepithelial collagen deposition that occurs in patients with collagenous colitis, a rare disease of unknown cause. One hypothesis considers an inflammatory origin, and the other, a local abnormality of collagen synthesis. An analysis of clinical, endoscopic, and histologic findings from one of our patients and from previously published cases suggests that collagenous colitis is a form of inflammatory bowel disease characterized by localization of the initial injury to the superficial subepithelial zone and with subsequent fibrosis in that area. The data show a spectrum of clinical and histologic changes that represent different stages in the evolution of the inflammatory process.

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