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The New Fluorinated Quinolones for Infection Prevention in Acute Leukemia

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Kuzell Institute for Arthritis and Infectious Diseases, and Pacific Presbyterian Medical Center, San Francisco, California

Ann Intern Med. 1987;106(1):144-146. doi:10.7326/0003-4819-106-1-144
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Prevention of bacterial infection has been a major goal of antileukemic therapy ever since it was recognized that cytotoxic and immunosuppressive agents strongly predispose neutropenic patients to acute bacteremia (1). The first efforts at antimicrobial and immunologic prophylaxis, however, were notably unsuccessful. Tetracyclines were initially used as oral prophylactic agents, but no success could be clearly shown (2). Two decades ago, gammaglobulin pooled from human sources by standard Cohn fractionation techniques was given to patients with acute leukemia and failed to influence the incidence or course of infection (3). More recently, use of prophylactic granulocyte transfusions appeared to lower the


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