0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Articles |

Pulmonary Function in Sickle Cell Trait

THOMAS A. DILLARD, M.D.; JOHN A. KARK, M.D.; KRISHNAN R. RAJAGOPAL, M.D.; JAMES A. KEY, M.A.; JAMES J. CANIK, B.S.; and CHARLES J. RUEHLE, M.D.
[+] Article and Author Information

Grant support: in part by protocol 9020-82 from the Walter Reed Army Medical Center.

The opinions and assertions contained herein are the private views of the authors and should not be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

◂Requests for reprints should be addressed to Krishnan R. Rajagopal, M.D.; Pulmonary Disease Service, Walter Reed Army Medical Center; Washington, DC 20307-5001.


Ann Intern Med. 1987;106(2):191-196. doi:10.7326/0003-4819-106-2-191
Text Size: A A A

Pulmonary function abnormalities, which have been reported to occur in persons with sickle cell trait (hemoglobin AS), could intensify the hypoxic stimulus for the systemic formation of sickle cells at high altitude. We sought to determine whether pulmonary function abnormalities occur as a result of exposure to high altitudes in persons with hemoglobin AS. In a prospective study, 13 men with hemoglobin AS ("cases") and 13 controls (hemoglobin AA) matched by age, sex, and race were exposed to five to seven altitude simulations (ranging from 1524 to 7620 m [5000 to 25 000 ft]) in a hypobaric chamber. Measurements of diffusing capacity for carbon monoxide (DLCO), forced vital capacity, forced expiratory volume in one second, and forced midexpiratory flow were obtained before and after each exposure. Data before exposures did not differ statistically between cases and controls. Altitude had no systematic effect on DLCO or Spirometric values in cases compared with values in controls (p > 0.05). Individual declines in forced vital capacity or DLCO of more than 10% occurred with similar frequency in both groups. Measurements made after the series of exposures showed no change from those made before. We conclude that short serial exposures to hypoxia at high altitudes does not acutely or cumulatively alter DLCO or spirometric values in healthy, nonexercising persons with sickle cell trait.

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Journal Club
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)