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Suprofen-Related Nephrotoxicity: A Distinct Clinical Syndrome

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▸ Requests for reprints should be addressed to Meyer D. Lifschitz, M.D., c/o Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive; San Antonio, TX 78284.

San Antonio, Texas

©1987 American College of PhysiciansAmerican College of Physicians

Ann Intern Med. 1987;106(2):235-238. doi:10.7326/0003-4819-106-2-235
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We describe a unique clinical syndrome of flank pain and acute renal failure that is associated with suprofen, a nonsteroidal anti-inflammatory drug that has recently been made available in the United States. In the initial 6 months of the drug's distribution in this country, at least 16 patients developed this syndrome. All 16 had acute flank pain and 13 developed mild reversible renal failure within 12 hours of ingestion of one to three suprofen capsules. This syndrome is unlike other nephrotoxic syndromes related to nonsteroidal anti-inflammatory drugs. The mechanism is not known.





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